Injectable Fillers & Biostimulators
PDRN / Polynucleotides
Also known as: Rejuran, Plinest, Nucleofill, Placentex
Pain Level
Moderate
Downtime
1-2 days
Sessions
Moxie did 1 session; many protocols use a course
Cost Range (AED)
Moxie's cost: AED 3,000-3,600
Results Timeline
Moxie saw glow and under-eye improvement; lasted about 3-4 months
Moxie Notes
From Moxie
I tried Rejuran in January 2026, mainly for my under-eyes. I had some product left, so my injector used the rest across my face and neck for glow. It did help my under-eye area and it did give that freshened-up skin look.
But at AED 3,000 to 3,600, I did not feel the difference was big enough or long-lasting enough to justify doing it every few months. If your skin quality is already strong, the result may be nice but not dramatic. I would repeat it only if I really felt I needed it.
Start Here
First, try this if
- Under-eye crepiness or tired-looking thin skin. - People wanting skin quality, not filler volume. - Sensitive or pigment-prone patients who are avoiding aggressive lasers. - Fitzpatrick III-VI skin tones, with injection-trauma bruising/PIH precautions.
Don't expect
Results build gradually, not overnight — realistic timeline is Moxie saw glow and under-eye improvement; lasted about 3-4 months.
See a dermatologist first if
- Fish or seafood allergy where salmon-derived products are used. - Pregnancy or breastfeeding unless cleared by a doctor. - Active infection at injection site. - Anyone expecting dramatic filler-like change.
What It Is
PDRN and polynucleotide injectables are regenerative skin boosters made from DNA fragments, commonly associated with products such as Rejuran, Plinest, Nucleofill and similar clinic brands. They are not HA fillers and are not meant to change facial structure.
They are used for skin quality: under-eye crepiness, texture, fine lines, dullness and sometimes post-procedure recovery. For topical PDRN serums (a separate, lower-confidence category), see the PDRN (Polydeoxyribonucleotide) ingredient page under Ingredients.
Moxie covers this injectable version because it is one of the most talked-about regenerative injectables, but the cost-to-result ratio matters.
How It Works
Polynucleotides are thought to support tissue repair pathways, fibroblast activity, extracellular matrix quality and inflammation modulation. PDRN is often discussed through adenosine receptor pathways and skin repair mechanisms. In practical terms, the aim is better skin quality, not volume.
The under-eye area is popular because it can look thin, crepey and tired after weight loss, but injections there can swell or bruise.
The Evidence
Concerns Addressed
Dark Circles / Under-Eye Crepiness: PDRN may help the look of thin, tired under-eye skin when quality is the issue. It does not replace volume if true hollowing is structural. Fine Lines & Crepey Skin: Evidence suggests improvement in texture, elasticity and wrinkle appearance in aesthetic use.
Evidence quality varies by exact product and indication. Recent reviews describe promising aesthetic outcomes for wrinkles, texture and elasticity, but also note that evidence varies by formulation and study design. The evidence is more convincing for skin quality than for every claim attached to PDRN marketing. Topical PDRN and injectable PDRN should not be treated as equivalent.
Small randomized and split-face trials support PDRN/polynucleotide injections for skin elasticity, dermal thickness, and texture (Korean phase III split-face study; 2020 split-face study). However, the evidence base itself is explicitly described in review literature as still needing large, high-quality standardized RCTs — current data show meaningful short-term benefit but with real heterogeneity across formulations and endpoints. Downgraded from the documented 'Strong' given this caveat.
View source →Reviewed by Moxie — last checked July 2026
Am I a Good Candidate?
- Under-eye crepiness or tired-looking thin skin. - People wanting skin quality, not filler volume. - Sensitive or pigment-prone patients who are avoiding aggressive lasers. - Fitzpatrick III-VI skin tones, with injection-trauma bruising/PIH precautions.
Caution or Avoid
- Fish or seafood allergy where salmon-derived products are used. - Pregnancy or breastfeeding unless cleared by a doctor. - Active infection at injection site. - Anyone expecting dramatic filler-like change.
What to Expect
Step 1 - Consultation: The doctor checks under-eye anatomy, crepiness versus hollowing, allergies and product suitability. Step 2 - Numbing: Numbing cream is usually used, especially under the eyes. Step 3 - The procedure: Microinjections are placed into the dermis or superficial tissue depending on area.
Step 4 - Immediately after: Small bumps, swelling and bruising can appear. Under-eyes can look puffy temporarily. Step 5 - Timeline and maintenance: Glow may appear within weeks, with stronger change after a series. Maintenance depends on response and budget.
Cost Breakdown
Personal cost recorded: AED 3,000-3,600 for Rejuran. Per session: Moxie's real cost range only. Full course: if repeated, multiply by the number of sessions advised. Maintenance: Moxie felt the visible effect lasted roughly 3-4 months. Figures are market estimates, not quotes.
Concerns Addressed
Frequently Asked Questions
What is PDRN used for in skincare treatments?
PDRN (polynucleotide) injectables — brands like Rejuran, Plinest or Nucleofill — are used for skin quality rather than structural change: texture, under-eye crepiness, fine lines and dullness, not volume.
How long do PDRN/Rejuran results last?
In Moxie's experience, the visible effect lasted roughly 3-4 months after one session; many clinic protocols use a full course rather than a single treatment for stronger or longer-lasting change.
Is PDRN safe for people with allergies?
Anyone with a fish or seafood allergy should flag this before treatment, since some PDRN products are salmon-derived — this is a specific caution to raise at consultation.
The Verdict
Worth Exploring
Nice, but expensive for the lifespan.
Moxie Ratings
Not medical advice. Content is based on personal experience and published research. Always consult a qualified dermatologist before starting any new treatment or regimen.
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